Enable Safe Mode default via Command Prompt (Elevated Mode)
bcdedit /set {default} safeboot minimal

Disable Safe Mode default via Command Prompt (Elevated Mode)
bcdedit /deletevalue {default} safeboot

Renable [F8] for entering Safe Mode
bcdedit /set {default} bootmenupolicy legacy
Note: This does not necessary work on systems configured with Fast Boot on SSD.

References to enabling windows 10 safe boot:

https://www.digitalcitizen.life/4-ways-boot-safe-mode-windows-10

https://home.bt.com/tech-gadgets/computing/windows-10/how-to-restart-windows-10-and-whatever-happened-to-safe-mode-11364000631724